Paxson C L, Stoerner J W, Denson S E, Adcock E W, Morriss F H
J Pediatr. 1977 Sep;91(3):459-63. doi: 10.1016/s0022-3476(77)81325-5.
Nine episodes of the syndrome of inappropriate antidiuretic hormone secretion occurred in five newborn infants following atelectasis or pneumothorax. All infants had pre-existing lung disease and were being treated with positive pressure ventilation. The mean interval between acute atelectasis or pneumothorax and the development of diagnostic hyponatremia, hypo-osmolal serum, hyperosmolal urine, and oliguria was 13.4 hours. Fluid restriction and removal of the triggering event resulted in resolution of the abnormalities within 1.5 to 4 days. Infants who develop atelectasis or pneumothorax should be evaluated for the subsequent occurrence of SIADH; the administration of a water load to them may result in dilutional hyponatremia, for which fluid restriction, not sodium infusion, is the proper therapy.
五名新生儿在肺不张或气胸后发生了九次抗利尿激素分泌异常综合征。所有婴儿均患有先天性肺部疾病，并接受正压通气治疗。急性肺不张或气胸与诊断性低钠血症、低渗血清、高渗尿液和少尿的发生之间的平均间隔为13.4小时。限制液体摄入并消除触发因素可使异常情况在1.5至4天内得到缓解。发生肺不张或气胸的婴儿应评估是否随后发生抗利尿激素分泌异常综合征；给他们给予水负荷可能会导致稀释性低钠血症，对此限制液体摄入而非输注钠才是正确的治疗方法。
