Frick A, Durasin I, Neuweg M
Pflugers Arch. 1981 Dec;392(2):99-105. doi: 10.1007/BF00581256.
The effect of hydrocortisone (HC) on the renal Pi transport in the presence and in the absence of parathyroid hormone (PTH) in the rat was examined using clearance techniques. During constant infusion of PTH in parathyroidectomized (PTX) rats, HC decreased the reabsorption of Pi from 2.84 to 2.33 mumol/min (P less than 0.001), the TmPi from 4.55 to 3.83 mumol/min (P less than 0.001), the reabs. Pi/GFR values from 0.93 to 0.74 (P less than 0.001) and the TmPi/GFR from 1.73 to 1.42 mumol/ml (P less than 0.001). In the absence of PTH, HC diminished the TmPi from 8.36 to 6.58 mumol/min (P less than 0.005) and the TmPi/GFR from 3.36 to 2.51 mumol/ml (P less than 0.001). It is concluded that the phosphaturic response of hydrocortisone may be important in the homeostasis of inorganic phosphate in the body.
采用清除率技术研究了氢化可的松（HC）在有和无甲状旁腺激素（PTH）存在的情况下对大鼠肾脏磷转运的影响。在对甲状旁腺切除（PTX）大鼠持续输注PTH期间，HC使磷的重吸收从2.84降至2.33μmol/分钟（P＜0.001），TmPi从4.55降至3.83μmol/分钟（P＜0.001），重吸收磷/肾小球滤过率（reabs. Pi/GFR）值从0.93降至0.74（P＜0.001），TmPi/GFR从1.73降至1.42μmol/毫升（P＜0.001）。在无PTH时，HC使TmPi从8.36降至6.58μmol/分钟（P＜0.005），TmPi/GFR从3.36降至2.51μmol/毫升（P＜0.001）。得出的结论是，氢化可的松的排磷反应可能在体内无机磷的稳态中起重要作用。
