Rurak A, Melzacka M, Danek L
Pol J Pharmacol Pharm. 1981 Oct;33(3):341-8.
Pharmacokinetics study of trazodone after iv, ip and po administration has been performed in rats. Trazodone was given to animals in a single or multiple doses of 20 mg/kg p. o. or ip, or in doses of 5 and 10 mg/kg iv. The levels of the drug in plasma and brain tissue were assayed spectrofluorometrically at predetermined time intervals. The results indicate that neither the route of administration nor the dosage schedule affects in significant manner the pharmacokinetics of trazodone, but the pharmacokinetic parameters depend upon the dose used. The affinity of the drug to blood and brain tissue is nearly the same, in contrast to imipramine which shows, a low affinity to blood and high affinity to brain tissue.
已在大鼠中进行了曲唑酮静脉注射、腹腔注射和口服给药后的药代动力学研究。以20mg/kg的单次或多次剂量经口或腹腔注射给予动物曲唑酮，或以5mg/kg和10mg/kg的剂量静脉注射给药。在预定的时间间隔用荧光分光光度法测定血浆和脑组织中的药物水平。结果表明，给药途径和给药方案均未对曲唑酮的药代动力学产生显著影响，但药代动力学参数取决于所用剂量。与对血液亲和力低而对脑组织亲和力高的丙咪嗪相反，该药物对血液和脑组织的亲和力几乎相同。
