Evaluation of the effect of indapamide on moderate benign essential hypertension complicated by airways obstruction.

Patients with chronic obstructive airways disease (COAD) who also have hypertension present a particular therapeutic problem, since beta-blockers are likely to cause or aggravate bronchospasm. In this study, 25 patients with COAD and moderate benign essential hypertension were treated with indapamide 2.5 mg daily. Over the 28 week study period, blood pressure had fallen by 48/30 mmHg (mean value). With standardized bronchodilator therapy respiratory function improved over the same period.