Larsen W J
Tissue Cell. 1977;9(3):373-94. doi: 10.1016/0040-8166(77)90001-5.
Gap junctions are plasma membrane specializations characterized as aggregates of intramembranous particles in two apposed membranes meeting particle-to-particle in the 2-4 nm intermembrane 'gap'. Recent thin-section and freeze-fracture evidence has revealed significant structural variations of gap junctional structure at various stages of development and from different organisms and tissues. It is suggested that a comparative analysis of these differences may provide clues to the specific biological functions(s) of these ubiquitous organelles.
间隙连接是一种质膜特化结构，其特征为在两个相对的膜中，膜内颗粒聚集在一起，在2 - 4纳米的膜间“间隙”中颗粒与颗粒相互对接。最近的超薄切片和冷冻蚀刻证据表明，在发育的各个阶段以及来自不同生物体和组织的间隙连接结构存在显著的结构差异。有人提出，对这些差异进行比较分析可能为这些普遍存在的细胞器的特定生物学功能提供线索。
