Larsen W J
Tissue Cell. 1983;15(5):645-71. doi: 10.1016/0040-8166(83)90041-1.
Traditionally, all gap junctions have been considered to be identical in structure and function throughout the animal kingdom. Functions ascribed to these membrane specializations have been fundamental and have not been thought to differ significantly with respect to their mechanism of action. More recent studies support the view, however, that structural and compositional diversity may reflect significant functional differences between gap junctions in different classes of tissue but no clear and definitive patterns have yet emerged. This review does not attempt to comprehensively analyze the totality of the vast gap junction and coupling literature but focuses instead upon those recent observations which raise new questions related to the biological activities of gap junctions in different tissues.
传统上，在整个动物界，所有的间隙连接在结构和功能上都被认为是相同的。这些膜特化结构所具有的功能一直是基础性的，并且在作用机制方面被认为没有显著差异。然而，最近的研究支持这样一种观点，即结构和组成的多样性可能反映了不同组织类型中间隙连接在功能上的显著差异，但尚未出现明确和确定的模式。本综述并不试图全面分析大量关于间隙连接和细胞间偶联的文献，而是聚焦于那些最近的观察结果，这些观察结果提出了与不同组织中间隙连接的生物学活性相关的新问题。
