Krishnamra N, Limlomwongse L
Proc Soc Exp Biol Med. 1981 Oct;168(1):65-71. doi: 10.3181/00379727-168-41236.
The hypocalcemic effect of gastrin and its possible mode of action were studied in rats. Gastrin (13 micrograms/100 g rat), injected intravenously led to a significant reduction in the plasma calcium concentrations. The release of endogenous gastrin by an intragastric phenylalanine instillation similarly led to a significant hypocalcemia in intact rat but not in antrectomized rat. Moreover, the protective role of endogenous gastrin against hypercalcemia induced by an intraduodenal infusion of CaCl2 (10 mg/100 g rat) was demonstrated. Gastrin (50 microgram/100 g rat) seems to have no influence on the net intestinal absorption of 45Ca. The removal of 45Ca from plasma was also unaffected by gastrin administration. The disappearance rate from plasma of 45Ca administered 17 hr previously was compared in sham, thyroidectomized (TX) and parathyroid-autotransplanted rats receiving saline or gastrin. The faster rate of disappearance of plasma 45Ca from plasma in gastrin-treated TX autoparathyroid-transplanted rats indicated the suppressive action of gastrin on the release of 45Ca from as yet unknown source(s).
在大鼠中研究了胃泌素的降钙作用及其可能的作用方式。静脉注射胃泌素（13微克/100克大鼠）导致血浆钙浓度显著降低。胃内注入苯丙氨酸使内源性胃泌素释放，同样导致完整大鼠出现显著的低钙血症，但在胃窦切除的大鼠中则未出现。此外，还证实了内源性胃泌素对十二指肠内注入氯化钙（10毫克/100克大鼠）诱导的高钙血症的保护作用。胃泌素（50微克/100克大鼠）似乎对45Ca的肠道净吸收没有影响。胃泌素给药也不影响血浆中45Ca的清除。比较了在接受生理盐水或胃泌素的假手术、甲状腺切除（TX）和甲状旁腺自体移植大鼠中，17小时前给予的45Ca从血浆中的消失率。胃泌素处理的TX甲状旁腺自体移植大鼠血浆中45Ca从血浆中消失的速度更快，表明胃泌素对来自未知来源的45Ca释放具有抑制作用。
