Ito H, Sakurada T, Orimo H
Horm Metab Res. 1977 Jan;9(1):89-92. doi: 10.1055/s-0028-1093591.
Following pyloric ligation, serum immunoreactive gastrin levels and gastric acid accumulation in acutely thyroidectomized rats with autotransplanted parathyroid glands were significantly higher than those in thyroid intact rats. Furthermore, serum immunoreactive gastrin levels were higher in the absence than in the presence of the thyroid gland following the oral administration of glycine or rat chaw. These results suggest that endogeneous calcitonin has an inhibitory action on gastric acid secretion probably through the inhibitory action on gastrin secretion in rats.
幽门结扎术后，自体移植甲状旁腺的急性甲状腺切除大鼠的血清免疫反应性胃泌素水平和胃酸积聚显著高于甲状腺完整的大鼠。此外，口服甘氨酸或大鼠食物后，无甲状腺的大鼠血清免疫反应性胃泌素水平高于有甲状腺的大鼠。这些结果表明，内源性降钙素可能通过对大鼠胃泌素分泌的抑制作用，对胃酸分泌具有抑制作用。
