Osborn J L, Francisco L L, DiBona G F
Proc Soc Exp Biol Med. 1981 Oct;168(1):77-81. doi: 10.3181/00379727-168-41238.
Renal nerve stimulation increases renal vascular resistance and decreases glomerular filtration rate and urinary sodium excretion. The purpose of this study was to determine whether neurally mediated changes in renal vascular resistance, glomerular filtration rate, and urinary sodium excretion at control renal perfusion pressure modified the autoregulation of renal blood flow and glomerular filtration rate and the antinatriuresis observed during reductions in renal perfusion pressure in pentobarbital-anesthetized dogs. Renal blood flow, glomerular filtration rate, and urinary sodium excretion were determined during stepwise reductions in renal perfusion pressure from 137 to 55 mm Hg (suprarenal aortic constriction) before and during electrical stimulation of the renal nerve at 0.5, 1.0, 2.0, and 4.0 Hz. In the absence of renal nerve stimulation, renal blood flow and glomerular filtration rate remained constant until renal perfusion pressure was reduced to 70 and 85 mm Hg, respectively. Urinary sodium excretion decreased linearly as renal perfusion pressure decreased. Renal nerve stimulation at 0.5, 1.0, 2.0, and 4.0 Hz increased renal vascular resistance and decreased glomerular filtration rate and urinary sodium excretion. These frequencies of renal nerve stimulation, however, did not alter the decreases in renal vascular resistance and glomerular filtration rate or the antinatriuretic response to stepwise reductions in renal perfusion pressure to 55 mm Hg. These data demonstrate that increased renal vascular resistance at either the afferent or efferent arteriole does not change the responses of these vessels to reductions in renal perfusion pressure. Renal nerve stimulation at frequencies which decrease urinary sodium excretion at control renal perfusion pressure also does not enhance the antinatriuretic response to reductions in renal perfusion pressure.
肾神经刺激会增加肾血管阻力，降低肾小球滤过率和尿钠排泄。本研究的目的是确定在戊巴比妥麻醉的犬中，在对照肾灌注压下神经介导的肾血管阻力、肾小球滤过率和尿钠排泄的变化是否会改变肾血流和肾小球滤过率的自身调节，以及在肾灌注压降低期间观察到的钠排泄减少。在肾神经分别以0.5、1.0、2.0和4.0Hz进行电刺激之前和期间，当肾灌注压从137mmHg逐步降低至55mmHg（肾上腺上主动脉缩窄）时，测定肾血流、肾小球滤过率和尿钠排泄。在没有肾神经刺激的情况下，肾血流和肾小球滤过率保持恒定，直到肾灌注压分别降至70mmHg和85mmHg。随着肾灌注压降低，尿钠排泄呈线性下降。以0.5、1.0、2.0和4.0Hz进行肾神经刺激会增加肾血管阻力，降低肾小球滤过率和尿钠排泄。然而，这些肾神经刺激频率并未改变肾血管阻力和肾小球滤过率的降低，也未改变对肾灌注压逐步降低至55mmHg时的抗利尿钠反应。这些数据表明，入球或出球小动脉处肾血管阻力增加不会改变这些血管对肾灌注压降低的反应。在对照肾灌注压下降低尿钠排泄的频率进行肾神经刺激，也不会增强对肾灌注压降低的抗利尿钠反应。
