Fricke H, Schade W, Härtl A, Drewello S
Pharmazie. 1981 Nov;36(11):763-7.
Turimycin H0 was isolated from the bile of rats as main metabolite after i.v. administration of turimycin H. It was also obtained by incubation of turimycin H with liver homogenates of dogs and rats. Degradation of turimycin H by liver homogenate of pigs was found to be relatively slow. Turimycin H0 was identified as 4"-deacylturimycin H by MS.
静脉注射土霉素H后，从大鼠胆汁中分离出土霉素H0作为主要代谢产物。通过将土霉素H与狗和大鼠的肝脏匀浆孵育也可得到土霉素H0。发现猪肝脏匀浆对土霉素H的降解相对较慢。通过质谱法鉴定出土霉素H0为4”-脱酰基土霉素H。
