[大环内酯类抗生素土霉素H主要代谢产物的分离与结构（作者译）]
[Isolation and structure of the main metabolite of macrolide antibiotic turimycin H (author's transl)].
作者信息
Fricke H, Schade W, Härtl A, Drewello S
出版信息
Pharmazie. 1981 Nov;36(11):763-7.
PMID:7323124
Abstract
Turimycin H0 was isolated from the bile of rats as main metabolite after i.v. administration of turimycin H. It was also obtained by incubation of turimycin H with liver homogenates of dogs and rats. Degradation of turimycin H by liver homogenate of pigs was found to be relatively slow. Turimycin H0 was identified as 4"-deacylturimycin H by MS.
摘要
静脉注射土霉素H后，从大鼠胆汁中分离出土霉素H0作为主要代谢产物。通过将土霉素H与狗和大鼠的肝脏匀浆孵育也可得到土霉素H0。发现猪肝脏匀浆对土霉素H的降解相对较慢。通过质谱法鉴定出土霉素H0为4”-脱酰基土霉素H。
相似文献
1
2
Pharmacokinetic characteristics of the new veterinary antibiotic turimycin.新型兽用抗生素图里霉素的药代动力学特征
Pol J Pharmacol Pharm. 1980 Mar-Apr;32(2):211-6.
3
Toxicological studies on the new veterinary antibiotic turimycin.新型兽用抗生素图里霉素的毒理学研究
Pol J Pharmacol Pharm. 1980 Mar-Apr;32(2):217-24.
4
[Protein binding of the macrolide antibiotic turimycin. Methodologic effects on results].[大环内酯类抗生素土霉素的蛋白结合。方法学对结果的影响]
Pharmazie. 1983 Nov;38(11):740-3.
5
[Pharmacokinetics of turimycin (proceedings)].[土霉素的药代动力学（会议论文集）]
Pharmazie. 1979 May-Jun;34(5-6):341-2.
6
HPLC-NMR with severe column overloading: fast-track metabolite identification in urine and bile samples from rat and dog treated with [14C]-ZD6126.高效液相色谱-核磁共振联用技术用于严重柱超载情况：快速鉴定经[14C]-ZD6126处理的大鼠和犬尿液及胆汁样本中的代谢产物
J Pharm Biomed Anal. 2007 Feb 19;43(3):1065-77. doi: 10.1016/j.jpba.2006.09.010. Epub 2006 Oct 9.
7
8
[Biochemical studies on acemetacin/Experimental tests in animals (author's transl)].阿西美辛的生化研究/动物实验测试（作者译）
Arzneimittelforschung. 1980;30(8A):1371-83.
9
[Antimicrobial activity in tissues of swine following subcutaneous administration of turimycin].
Arch Exp Veterinarmed. 1983 Jul;37(4):599-607.
10
Disposition and metabolism of the new hypocholesterolemic compound S-8921 in rats and dogs.新型降胆固醇化合物S-8921在大鼠和犬体内的处置与代谢
Arzneimittelforschung. 1998 Oct;48(10):995-1006.
Zotero 插件