Laurian S, Le P K, Baumann P, Perey M, Gaillard J M
Pharmacopsychiatria. 1981 Nov;14(6):199-204. doi: 10.1055/s-2007-1019598.
The effect of chlorpromazine (CPZ) was studied at four different doses in a group of 10 normal subjects. Blood levels of CPZ were assayed by gas chromatography and showed wide interindividual variations. Spontaneous brain electrical activity (EEG) was recorded from 8 leads and submitted to spectral analysis. Evoked responses (ER) to flashes, pattern reversals and clicks were averaged, and measured by their amplitude and variability. Several subjects presented marked side-effects (responders, R) and showed differences in many EEG parameters with respect to subjects without side-effects (non-responders, NR). A cluster analysis permitted to distinguish very clearly these two groups of subjects. The differences in the effects of CPZ between the R and NR groups involved mainly EEG, and appeared with a systematic topography over the scalp. Within the R group, many differences were observed as a function of the dose of CPZ; they consisted mainly in a decrease of alpha and an increase of theta activity in the EEG, decrease of amplitude and increase of variability in the ER measures. These modifications had also a typical topography over the scalp. Finally, many variables of EEG (relative power only) were correlated with plasma level of CPZ, while no such correlation appeared for ER. These results are discussed in terms of individual sensitivity to drugs, relationships between EEG parameters and plasma level, and topographical differences in the effect of CPZ.
在一组10名正常受试者中研究了四种不同剂量氯丙嗪（CPZ）的效果。通过气相色谱法测定CPZ的血药浓度，结果显示个体间差异很大。从8个导联记录自发脑电活动（脑电图）并进行频谱分析。对闪光、图形翻转和咔哒声的诱发电位（ER）进行平均，并通过其振幅和变异性进行测量。一些受试者出现明显的副作用（反应者，R），并且在许多脑电图参数方面与无副作用的受试者（无反应者，NR）存在差异。聚类分析能够非常清楚地区分这两组受试者。R组和NR组之间CPZ效果的差异主要涉及脑电图，并且在头皮上呈现出系统性的分布特征。在R组内，观察到许多随CPZ剂量变化的差异；主要表现为脑电图中α波减少和θ波活动增加，ER测量中振幅降低和变异性增加。这些变化在头皮上也有典型的分布特征。最后，许多脑电图变量（仅相对功率）与CPZ血浆水平相关，而ER未出现这种相关性。根据个体对药物的敏感性、脑电图参数与血浆水平之间的关系以及CPZ效果的分布差异对这些结果进行了讨论。
