Rodeghiero F, Morbin M, Barbui T
Ric Clin Lab. 1981 Oct-Dec;11(4):333-6. doi: 10.1007/BF02909031.
The search for activated products of coagulation factors in blood is of considerable clinical interest because its detection would indicate activation of the clotting system. Factor XIII circulates as inactive zymogen and becomes enzymatically active after thrombin or factor Xa activation. Employing an amine-incorporating system, activated factor XIII was measured in normal and pathological plasma from leukemic patients with overt laboratory signs of disseminated intravascular coagulation (DIC). Only traces of the activated factor were detected in both normal and DIC plasma. The method, sensitive and specific, as shown by the results of measurements on the plasma of 8 patients with congenital deficiency and on normal serum, did not prove to be useful for detecting pathological in vivo thrombin generation.
对血液中凝血因子活化产物的研究具有重要的临床意义，因为其检测可表明凝血系统的激活。因子 XIII 以无活性的酶原形式循环，在凝血酶或因子 Xa 激活后具有酶活性。采用胺掺入系统，对有明显实验室弥散性血管内凝血（DIC）迹象的白血病患者的正常和病理血浆中的活化因子 XIII 进行了检测。在正常血浆和 DIC 血浆中均仅检测到痕量的活化因子。该方法对 8 例先天性缺乏患者的血浆和正常血清进行检测的结果表明，它灵敏且特异，但并未证明对检测体内病理性凝血酶生成有用。
