Uchikoshi S, Nomura K, Saitoh S, Komatsu N, Chien C, Miyake H
Tokai J Exp Clin Med. 1981 Oct;6(4):363-71.
During a three-year period from 1976, we examined fifty eight patients with nasal allergy who worked in spinning mills or handled sewing machines. Skin tests and procative nasal tests were performed on these patients with crude and fractionated extracts from cotton linters, cotton cloth and chemical fibers. The crude aqueous antigens were extracted in dextro-phenol solution and fractionated by Saphadex G-100. It was possible that the cotton and chemical fibers included components which were the cause of hypersensitivity, but there is still doubts concerning their reaction as irritant substances. Serum specific IgE antibody was found in extracts from chemical fiber. Therefore, spinning mill dust acts as an irritant of the nose add the possibility of antigenicity of the dust for immediate type nasal allergies can not be denied from the present study.
从1976年起的三年时间里，我们检查了58名在纺织厂工作或操作缝纫机的鼻过敏患者。用棉绒、棉布和化学纤维的粗提物及分级提取物对这些患者进行了皮肤试验和激发鼻试验。粗制水性抗原在右旋酚溶液中提取，并用Saphadex G - 100分级。棉花和化学纤维可能含有导致过敏的成分，但对于它们作为刺激性物质的反应仍存在疑问。在化学纤维提取物中发现了血清特异性IgE抗体。因此，纺织厂粉尘可作为鼻部刺激物，且从本研究中不能排除粉尘对速发型鼻过敏具有抗原性的可能性。
