Nilius B, Schüttler K, Boldt W
Acta Biol Med Ger. 1981;40(6):821-9.
Repetitive activity of the isolated rabbit atrium was induced by trains of premature stimuli. Analyzing the interval-histograms of the recorded atrial action potentials a quantitative description of this arrhythmia is demonstrated. An atrial flutter or fibrillation is evoked 110 to 140 ms after a regular driving pulse. Vagal stimulation increases the electrical vulnerability. The degree of arrhythmia was found to be dependent on the frequency of stimulation. During increased vagal activity premature stimuli applied 40 to 190 ms after a regular driving pulse generate arrhythmias. By vagal stimulation a preexisting arrhythmia is converted into an atrial fibrillation. In spite of a constant pacing, the atrial arrhythmia disappears at atrial masses of below 55 mg if initiated by early coupled beats. During an application of acetylcholine this critical mass is reduced.
通过一串期前刺激诱导离体兔心房的重复活动。分析记录的心房动作电位的间期直方图，展示了对这种心律失常的定量描述。在规则驱动脉冲后110至140毫秒诱发心房扑动或颤动。迷走神经刺激增加电易损性。发现心律失常的程度取决于刺激频率。在迷走神经活动增强期间，在规则驱动脉冲后40至190毫秒施加的期前刺激会产生心律失常。通过迷走神经刺激，先前存在的心律失常会转变为心房颤动。尽管起搏恒定，但如果由早期联律搏动引发，当心房质量低于55毫克时心房心律失常会消失。在应用乙酰胆碱期间，这个临界质量会降低。
