Lack of influence on collagen accumulation in granulation tissue with 'delayed' defibrinogenation. A study in the rabbit.

Systemic defibrinogenation using Arvin delays wound strength development and collagen accumulation in sponge-induced granulation tissue. Whether this effect is due to interference with the initial fibrin deposition or to any inhibiting action on fibroblast function has not been decided. In the present study the administration of Arvin is started after the initial formation of a fibrin framework. No effect on collagen accumulation in granulation tissue was demonstrated, suggesting that the action of Arvin on wound healing is limited to the first phase of wound healing and that a normal fibrin deposition is necessary for a normal healing process.