Brändstedt S, Olson P S, Ahonen J
Acta Chir Scand. 1980;146(8):551-3.
Collagen synthesis was studied in sponge-induced early granulation tissue from rabbits defibrinogenated by Arvin. Tissue slices were incubated in vitro with 14C-proline. The formation of 14C-hydroxyproline and the incorporation of 14C-proline into proteins was determined. The incorporation of proline into collagen and proteins was equally reduced after defibrinogenation. A possible explanation for this is a reduced number of active fibroblasts in granulation tissue formed during defibrinogenation.
在被蛇毒去纤维蛋白酶使纤维蛋白原减少的家兔的海绵诱导早期肉芽组织中研究了胶原蛋白的合成。将组织切片与14C-脯氨酸在体外进行孵育。测定了14C-羟脯氨酸的形成以及14C-脯氨酸掺入蛋白质的情况。去纤维蛋白原后，脯氨酸掺入胶原蛋白和蛋白质的量均同等减少。对此的一种可能解释是，在去纤维蛋白原过程中形成的肉芽组织中活性成纤维细胞数量减少。
