Magyar I, Loi H G, Fehér T
Acta Med Acad Sci Hung. 1981;38(2):109-15.
The plasma cholic acid, chenodesoxycholic acid and desoxycholic acid levels were studied by spectrofluoremetry in 153 cases. The values of 67 controls with no evidence of hepatobiliary or intestinal disease were compared with those of 86 patients with liver and biliary tract disease. The fasting values failed to provide more diagnostic information than did conventional laboratory assays. Plasma bile acid concentrations exceeding 2.5 mu mol/l are conclusive of liver or biliary disease. A cholic acid/chenodesoxycholic acid quotient higher than 1.0 is a sign of cholestasis. Estimation of bile acids after food intake was found more informative. The plasma cholic acid- and chenodesoxycholic acid levels underwent a considerable increase 1 to 2 hours after meals. A more marked increase of chenodesoxycholic acid than of cholic acid (the ratio of the two being in excess of 1.0) is indicative of cholestasis and is most marked in primary biliary cirrhosis.
采用荧光分光光度法对153例患者的血浆胆酸、鹅去氧胆酸和脱氧胆酸水平进行了研究。将67例无肝胆或肠道疾病证据的对照者的值与86例肝胆疾病患者的值进行了比较。空腹值未能提供比传统实验室检测更多的诊断信息。血浆胆汁酸浓度超过2.5μmol/L可确诊为肝脏或胆道疾病。胆酸/鹅去氧胆酸商高于1.0是胆汁淤积的标志。发现进食后胆汁酸的测定更具信息量。进食后1至2小时，血浆胆酸和鹅去氧胆酸水平显著升高。鹅去氧胆酸比胆酸升高更明显（两者之比超过1.0）提示胆汁淤积，在原发性胆汁性肝硬化中最为明显。
