瘙痒机制与回路。
Itch mechanisms and circuits.
机构信息
The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology.
出版信息
Annu Rev Biophys. 2014;43:331-55. doi: 10.1146/annurev-biophys-051013-022826.
Abstract
The itch-scratch reflex serves as a protective mechanism in everyday life. However, chronic persistent itching can be devastating. Despite the clinical importance of the itch sensation, its mechanism remains elusive. In the past decade, substantial progress has been made to uncover the mystery of itching. Here, we review the molecules, cells, and circuits known to mediate the itch sensation, which, coupled with advances in understanding the pathophysiology of chronic itching conditions, will hopefully contribute to the development of new anti-itch therapies.
摘要
抓挠反射在日常生活中起着保护机制的作用。然而，慢性持续性瘙痒可能是毁灭性的。尽管瘙痒感觉具有临床重要性，但它的机制仍然难以捉摸。在过去的十年中，人们在揭示瘙痒之谜方面取得了重大进展。在这里，我们回顾了已知介导瘙痒感觉的分子、细胞和回路，这些进展加上对慢性瘙痒症发病机制的理解的提高，有望有助于开发新的止痒疗法。
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本文引用的文献
1
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Exp Dermatol. 2013 Aug;22(8):530-4. doi: 10.1111/exd.12189. Epub 2013 Jun 27.
2
The ion channel TRPA1 is required for chronic itch.离子通道 TRPA1 是慢性瘙痒所必需的。
J Neurosci. 2013 May 29;33(22):9283-94. doi: 10.1523/JNEUROSCI.5318-12.2013.
3
The cells and circuitry for itch responses in mice.小鼠瘙痒反应的细胞和回路。
Science. 2013 May 24;340(6135):968-71. doi: 10.1126/science.1233765.
4
Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.活动依赖性沉默揭示了具有不同功能的痒觉产生感觉神经元。
Nat Neurosci. 2013 Jul;16(7):910-8. doi: 10.1038/nn.3404. Epub 2013 May 19.
5
Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.兴奋性背角浅层中间神经元在功能上具有异质性，是痛觉和痒觉完全表达行为所必需的。
Neuron. 2013 Apr 24;78(2):312-24. doi: 10.1016/j.neuron.2013.03.001.
6
Mechanically evoked itch in humans.人体机械性诱发瘙痒。
Pain. 2013 Jun;154(6):897-904. doi: 10.1016/j.pain.2013.02.021. Epub 2013 Mar 1.
7
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