Winnem B, Samstad B, Breivik H
Acta Anaesthesiol Scand. 1981 Jun;25(3):209-14. doi: 10.1111/j.1399-6576.1981.tb01638.x.
Eighty patients took part in this double-blind, single-dose group-comparative study, comparing the analgesic efficacy of tiaramide hydrochloride 100 mg and 200 mg, paracetamol 1000 mg, and placebo for pain after orthopedic operations. The four treatment groups were similar on entry to the trial. Pain relief was assessed up to 6 h after treatment, using a visual analogue pain scale and a pain score, both giving similar results. Statistically significant pain relief (mean pain intensity differences and sum of pain intensity differences) was seen in the group receiving paracetamol compared to those receiving placebo or tiaramide from 1 h to 6 h after drug ingestion. There was no significant difference between placebo and tiaramide 100 or 200 mg. No adverse reactions were reported.
80名患者参与了这项双盲、单剂量组间比较研究，比较了100毫克和200毫克盐酸替拉米特、1000毫克对乙酰氨基酚以及安慰剂对骨科手术后疼痛的镇痛效果。四个治疗组在进入试验时情况相似。治疗后长达6小时使用视觉模拟疼痛量表和疼痛评分评估疼痛缓解情况，两者结果相似。与服用安慰剂或替拉米特的组相比，服用对乙酰氨基酚的组在服药后1小时至6小时出现了具有统计学意义的疼痛缓解（平均疼痛强度差异和疼痛强度差异总和）。安慰剂与100毫克或200毫克替拉米特之间没有显著差异。未报告不良反应。
