Yates D W, Laing G S, Peters K, Kumar K
Arch Emerg Med. 1984 Dec;1(4):197-203. doi: 10.1136/emj.1.4.197.
A prospective controlled trial involving over 1000 patients did not reveal any difference between four drugs commonly used in accident and emergency departments for the relief of mild to moderate pain. There were no significant variations in therapeutic effect, side-effects or patient compliance. When considering the supply of analgesics which may be no more potent than those available without prescription from retail chemists, cost and safety are more important than analgesic effect. By restricting the choice of analgesics available, the accident and emergency department should be able to increase awareness among its staff of the actions and side-effects of a small number of prescribed drugs and to contain costs.
一项涉及1000多名患者的前瞻性对照试验并未发现急诊科常用的四种缓解轻至中度疼痛的药物之间存在任何差异。在治疗效果、副作用或患者依从性方面没有显著差异。在考虑供应可能并不比从零售药店无需处方就能买到的药物效力更强的镇痛药时，成本和安全性比镇痛效果更重要。通过限制可用镇痛药的选择，急诊科应该能够提高其工作人员对少数处方药的作用和副作用的认识，并控制成本。
