Marty J, Desmonts J M
Acta Anaesthesiol Scand. 1981 Jun;25(3):293-6. doi: 10.1111/j.1399-6576.1981.tb01654.x.
The effects of fentanyl on total respiratory pressure-volume relationship were studied in 12 supine, anesthetized (thiopental, succinylcholine, halothane, N2O/O2) children, 5, 10 and 15 min after administration of fentanyl, 3 micrograms/kg (Group F) and at similar intervals in 11 control, anesthetized children who did not receive fentanyl (Group C). Lung and chest wall pressure-volume relationships were measured in five children from Group F and in six from Group C. Compliance values were estimated from the linear part of PVR curves. In Group F, a significant decrease was observed at 5, 10 and 15 min (maximum 29%) for total compliance and at 15 min (maximum 26%) for lung compliance. Chest wall compliance was reduced (maximum 45%) at 15 min, but not significantly. In Group C, no change in compliances was noted. The comparison between the two groups for total, chest wall and lung compliances showed a significant decrease in these three parameters at 15 min in children receiving fentanyl. The decrease of chest wall compliance can be explained by increased muscle tone, but the mechanism of decreased lung compliance awaits further study.
在12名仰卧位、麻醉（硫喷妥钠、琥珀酰胆碱、氟烷、N2O/O2）的儿童中，研究了芬太尼对总呼吸压力-容积关系的影响。这些儿童在静脉注射3微克/千克芬太尼后5分钟、10分钟和15分钟（F组），并在11名未接受芬太尼的对照麻醉儿童中在相似的时间间隔进行观察（C组）。对F组的5名儿童和C组的6名儿童测量了肺和胸壁压力-容积关系。根据压力-容积反应（PVR）曲线的线性部分估算顺应性值。在F组中，总顺应性在5分钟、10分钟和15分钟时显著降低（最大降低29%），肺顺应性在15分钟时显著降低（最大降低26%）。胸壁顺应性在15分钟时降低（最大降低45%），但无统计学意义。在C组中，顺应性无变化。两组之间总顺应性、胸壁顺应性和肺顺应性的比较显示，接受芬太尼的儿童在15分钟时这三个参数显著降低。胸壁顺应性降低可由肌张力增加来解释，但肺顺应性降低的机制有待进一步研究。
