Lai Y L, Rodarte J R, Hyatt R E
J Appl Physiol Respir Environ Exerc Physiol. 1979 Apr;46(4):716-20. doi: 10.1152/jappl.1979.46.4.716.
Pressure-volume (PV) and conductance-volume (GV) curves were obtained in trained dogs awake and then anesthetized with thiopental sodium, in the prone left lateral decubitus, and supine positions. By paired analyses, induction of anesthesia had no significant effect on lung volumes, static PV curves of the lung or chest wall, or static compliance of the lung or chest wall. In addition, change of posture had little effect on these variables in either the awake or the anesthetized state. Frequently, however, individual dogs showed changes in lung PV curves after induction of anesthesia or change of posture. These PV curve shifts were not accompanied by predictable changes in GV relations. Therefore, we concluded that such changes in the lung PV curve reflect either local artifacts or local deformation of the respiratory system.
在清醒且经训练的犬只身上获取压力-容积（PV）曲线和电导-容积（GV）曲线，然后用硫喷妥钠对其进行麻醉，使其处于左侧卧位俯卧及仰卧位。通过配对分析，麻醉诱导对肺容积、肺或胸壁的静态PV曲线以及肺或胸壁的静态顺应性均无显著影响。此外，在清醒或麻醉状态下，体位改变对这些变量的影响均很小。然而，在很多情况下，个别犬只在麻醉诱导或体位改变后肺PV曲线会出现变化。这些PV曲线的偏移并未伴随着GV关系的可预测变化。因此，我们得出结论，肺PV曲线的此类变化反映的要么是局部伪影，要么是呼吸系统的局部变形。
