Andersen G E, Hejl M, Christensen N C, Bott H, Lous P, Friis-Hansen B
Acta Paediatr Scand. 1981 Nov;70(6):843-9. doi: 10.1111/j.1651-2227.1981.tb06237.x.
1407 children whose fathers had died from ischemic heart disease before age 45 were investigated. 15% had hypercholesterolemia and 8% hypertriglyceridemia at visit 1. At visit 2 and 3 this number of children with hyperlipemia fell to a minimum of 3% and 1.4%, resp. which is around 10 times higher than in a reference population. 1.8% of the children had familial hypercholesterolemia (FH) which is 10-15 times higher than in a reference population. These findings indicate that serum lipids should always be measured in children from such coronary heart risk families, and a decision made whether or not their permanent hyperlipemia should be treated.
对1407名父亲在45岁之前死于缺血性心脏病的儿童进行了调查。在第一次就诊时,15%的儿童患有高胆固醇血症,8%患有高甘油三酯血症。在第二次和第三次就诊时,患有高脂血症的儿童数量分别降至最低的3%和1.4%。这一比例比参考人群高出约10倍。1.8%的儿童患有家族性高胆固醇血症(FH),这一比例比参考人群高出10至15倍。这些发现表明,对于来自此类冠心病风险家庭的儿童,应始终检测其血脂,并决定是否应对其持续性高脂血症进行治疗。