Odumosu A, Wilson C W
Int J Vitam Nutr Res. 1980;50(1):52-60.
The distribution of ascorbic acid has been compared in the fore-, mid- and hind-brains of guinea-pigs maintained on a scorbutogenic diet alone, or the diet with supplementary Vitamin C, or the supplemented diet and a terminal convulsant dose of leptazol after 27 days. At the beginning of the investigation, mid-brain ascorbic acid concentrations were similar in both sexes and highest in the mid-brain. After 27 days on the supplemented diet, levels of ascorbic acid were raised in all three brain sections and were still highest in the mid-brains. In the scorbutic group, ascorbic acid concentrations had not changed from control levels in the mid-brain, but had fallen in the other two sections. In a dose-range of 40-60 mg/kg, leptazol caused an increase in convulsive index, and progressive depletion of brain ascorbic acid. No change occurred in fore-brain ascorbic acid, a reduction took place in the hindbrain, and the greatest fall occurred in the mid-brain. It is concluded that ascorbic acid plays an essential role in mid-brain metabolism, and that the convulsant effect of leptazol is influenced by an interaction with brain ascorbic acid.
已对豚鼠前脑、中脑和后脑抗坏血酸的分布情况进行了比较。这些豚鼠分别仅采用致坏血病饮食喂养，或采用补充维生素C的饮食喂养，或采用补充饮食并在27天后给予致死性惊厥剂量的戊四氮。在研究开始时，两性的中脑抗坏血酸浓度相似，且在中脑中最高。补充饮食27天后，所有三个脑区的抗坏血酸水平均升高，且中脑的抗坏血酸水平仍然最高。在坏血病组中，中脑的抗坏血酸浓度与对照组相比没有变化，但其他两个脑区的抗坏血酸浓度下降。在40 - 60毫克/千克的剂量范围内，戊四氮导致惊厥指数增加，并使脑抗坏血酸逐渐耗竭。前脑抗坏血酸无变化，后脑抗坏血酸减少，中脑抗坏血酸下降幅度最大。结论是抗坏血酸在中脑代谢中起重要作用，戊四氮的惊厥作用受其与脑抗坏血酸相互作用的影响。
