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HLA系统中杂种优势的证据。

Evidence for heterosis in the HLA system.

作者信息

Black F L, Salzano F M

出版信息

Am J Hum Genet. 1981 Nov;33(6):894-9.

Abstract

The number of persons with homozygous HLA haplotypes in several groups of South American Indians was 39% less than that expected assuming unmodified equilibrium. In a subpopulation of 122 persons whose parents' HLA constitutions were known, there were 56% fewer homozygous persons than expected. This deficit was widely distributed in different haplotypes and different tribal groups.

摘要

几组南美印第安人中纯合 HLA 单倍型的人数比假设平衡未改变时预期的人数少 39%。在一个由 122 人组成的亚群体中,其父母的 HLA 构成已知,纯合子人数比预期少 56%。这种不足在不同的单倍型和不同的部落群体中广泛分布。

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本文引用的文献

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HLA antigens in South American Indians.
Tissue Antigens. 1980 Nov;16(5):368-76. doi: 10.1111/j.1399-0039.1980.tb00317.x.
8
Selective pressure on HL-A polymorphism.对HL-A多态性的选择压力。
Nature. 1974 May 3;249(452):62-3. doi: 10.1038/249062a0.

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