主要组织相容性复合体和微卫星位点的遗传变异：大角羊的比较研究
Genetic variation of major histocompatibility complex and microsatellite loci: a comparison in bighorn sheep.
作者信息
Boyce W M, Hedrick P W, Muggli-Cockett N E, Kalinowski S, Penedo M C, Ramey R R
机构信息
Department of Veterinary Pathology, Microbiology and Immunology, University of California, Davis 95616, USA.
出版信息
Genetics. 1997 Feb;145(2):421-33. doi: 10.1093/genetics/145.2.421.
Abstract
Examining and comparing genetic variation for major histocompatibility complex (MHC) and micro-satellite (MS) loci in the same individuals provides an opportunity to understand the forces influencing genetic variation. We examined five MHC and three MS loci in 235 bighorn sheep (Ovis canadensis) from 14 populations and found that both types of loci were highly variable and were in Hardy-Weinberg proportions. Mean FST values for both markers were very similar and MHC and MS genetic variability was predominantly distributed within rather than among populations. However, analyses of genetic distances and tree topologies revealed different spatial patterns of variation for the two types of loci. Collectively, these results indicated that neutral forces substantially influenced MS and MHC variation, and they provided limited evidence for selection acting on the MHC.
摘要
在同一个体中检查和比较主要组织相容性复合体（MHC）和微卫星（MS）位点的遗传变异，为了解影响遗传变异的因素提供了一个契机。我们在来自14个种群的235只大角羊（加拿大盘羊）中检测了5个MHC位点和3个MS位点，发现这两类位点都具有高度变异性，并且处于哈迪-温伯格平衡比例。两种标记的平均FST值非常相似，MHC和MS的遗传变异主要分布在种群内部而非种群之间。然而，对遗传距离和树形拓扑结构的分析揭示了这两类位点不同的空间变异模式。总体而言，这些结果表明中性力量对MS和MHC变异有重大影响，并且它们为作用于MHC的选择提供了有限的证据。
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