Riviere J E, Coppoc G L
Am J Vet Res. 1981 Sep;42(9):1621-3.
The pharmacokinetics of gentamicin and/or creatinine clearances were investigated in eleven 5-month-old Beagles. A 2-compartment open model was used to describe the drug's disposition, as judged by error sums of squares and residual plot analyses. Half-life (elimination phase) was 60.9 +/- 7.8 minutes (mean +/- SD), the volume of distribution calculated from the area under the curve was 35.4 +/- 3.6 L/100 kg of body weight, and the clearance of the drug from the body was 4.08 +/- 0.62 ml/min/kg of body weight. The 24-hour creatinine renal clearance in these dogs was 3.82 +/- 0.92 ml/min/kg, consistent with gentamicin being eliminated mainly by glomerular filtration. Other pharmacokinetic values were also determined.
在11只5月龄的比格犬中研究了庆大霉素的药代动力学和/或肌酐清除率。通过误差平方和与残差图分析判断，采用二室开放模型描述药物的处置过程。半衰期（消除相）为60.9±7.8分钟（平均值±标准差），根据曲线下面积计算的分布容积为35.4±3.6升/100千克体重，药物从体内的清除率为4.08±0.62毫升/分钟/千克体重。这些犬的24小时肌酐肾清除率为3.82±0.92毫升/分钟/千克，这与庆大霉素主要通过肾小球滤过清除一致。还测定了其他药代动力学值。
