低剂量多巴胺对犬妥布霉素药代动力学的影响。
Effect of low-dose dopamine on the pharmacokinetics of tobramycin in dogs.
作者信息
Kirby M G, Dasta J F, Armstrong D K, Tallman R
出版信息
Antimicrob Agents Chemother. 1986 Jan;29(1):168-70. doi: 10.1128/AAC.29.1.168.
Abstract
Low-dose dopamine or a placebo was given to six healthy mongrel dogs, each receiving tobramycin at 2.0 mg/kg on consecutive days in a randomized crossover fashion. Dopamine increased the total and renal clearances and elimination rate constant of tobramycin by 12.5, 20, and 25.9%, respectively, suggesting that low-dose dopamine increases the clearance of tobramycin in dogs primarily through renal mechanisms.
摘要
给6只健康杂种犬给予低剂量多巴胺或安慰剂，每只犬连续数天以随机交叉方式按2.0mg/kg接受妥布霉素。多巴胺使妥布霉素的总清除率、肾脏清除率和消除速率常数分别增加了12.5%、20%和25.9%，提示低剂量多巴胺主要通过肾脏机制增加犬体内妥布霉素的清除率。
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本文引用的文献
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Renal disposition of gentamicin, dibekacin, tobramycin, netilmicin, and amikacin in humans.庆大霉素、地贝卡星、妥布霉素、奈替米星和阿米卡星在人体内的肾脏处置情况。
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