Grosshans E, Dungler T, Hanau D
Ann Dermatol Venereol. 1981;108(11):837-46.
The trichodiscoma first described by Pinkus (1966) is a small cutaneous tumor of the human retropilar hair disk; these lesions generally multiple and probably more common than previously appreciated occur in adult patients most often associated with perifollicular fibromas and acrochordons. We observed 2 female patients (39 and 47-year-old) with multiple trichodiscomas; a linear group of 7 tumors on the scalp in the first and multiple lesions disseminated on the chest in the second. Histologically and--in one case--electronmicroscopically the most striking features are: the paucity of the Merkel's cells in the overlying basal layer of the epidermis, the hyperplasia of the capillary blood vessels and of their endothelial cells, the presence of thick myelinated nerve fibers in the depth of the lesion but not in the vicinity of the epidermis, the proliferation of a loose dermal connective tissue, the occurrence of sparse hair follicles connected to the trichodiscoma but frequently located on its margin. One can conclude that trichodiscoma mainly consists of a hyperplasia of the dermal components of the hair disk; Merkel's cells though belonging to the normal hair disk are not involved in the histogenesis of the tumour. In his comprehensive paper (1974), Pinkus predicted that the description of the trichodisoma will lead to the identification of patients having only one or a few lesions: our first case may be considered as a circumscribed paucilesional clinical form.
平库斯（1966年）首次描述的毛发盘瘤是一种人类毛根后毛发盘的小型皮肤肿瘤；这些损害通常为多发性，可能比以往认识到的更为常见，发生于成年患者，最常与毛囊周围纤维瘤和皮赘相关。我们观察了2例患有多发性毛发盘瘤的女性患者（39岁和47岁）；第一例患者头皮上有一组呈线性排列的7个肿瘤，第二例患者胸部有多个散在的损害。在组织学上，以及在一例中通过电子显微镜观察，最显著的特征是：表皮上层基底细胞层中默克尔细胞数量稀少，毛细血管及其内皮细胞增生，损害深处有粗大的有髓神经纤维，但表皮附近没有，疏松的真皮结缔组织增生，有稀疏的毛囊与毛发盘瘤相连，但常位于其边缘。可以得出结论，毛发盘瘤主要由毛发盘的真皮成分增生构成；默克尔细胞虽属于正常毛发盘，但不参与肿瘤的组织发生。在其综合性论文（1974年）中，平库斯预测毛发盘瘤的描述将有助于识别仅有一个或少数几个损害的患者：我们的第一例病例可被视为一种局限性少发性的临床类型。
