从金黄色葡萄球菌临床分离株中获得的耐利福平变异株的特征。
Characteristics of rifampin-resistant variants obtained from clinical isolates of Staphylococcus aureus.
作者信息
Moorman D R, Mandell G L
出版信息
Antimicrob Agents Chemother. 1981 Dec;20(6):709-13. doi: 10.1128/AAC.20.6.709.
Abstract
Twenty clinical isolates of Staphylococcus aureus were examined to determine the frequency of rifampin-resistant variants. All isolates were highly susceptible to rifampin, with mean minimum inhibitory concentrations of 0.11 +/- 0.1 microgram/ml and mean minimum bactericidal concentrations of 0.22 +/- 0.2 microgram/ml. The frequency of isolation of resistant variants was similar to all rifampin concentrations tested. Rifampin-resistant variants maintained their resistance upon daily subculture in rifampin-free broth. Rifampin-susceptible S. aureus exhibited a growth and survival advantage over the rifampin-resistant mutants both in pure cultures and in mixtures with rifampin-resistant antecedents. A comparison of the virulence for mice of five susceptible isolates and their 100 microgram/ml-rifampin-resistant variants showed that two of the resistant variants were less virulent than the susceptible strains via intraperitoneal challenge, whereas three of the resistant variants were less virulent by intravenous challenge (P less than 0.05).
摘要
检测了20株金黄色葡萄球菌临床分离株，以确定耐利福平变异株的频率。所有分离株对利福平高度敏感，平均最低抑菌浓度为0.11±0.1微克/毫升，平均最低杀菌浓度为0.22±0.2微克/毫升。在所有测试的利福平浓度下，耐药变异株的分离频率相似。耐利福平变异株在不含利福平的肉汤中每日传代培养后仍保持其耐药性。在纯培养物中以及与耐利福平亲代混合培养时，对利福平敏感的金黄色葡萄球菌比耐利福平突变体具有生长和存活优势。对5株敏感分离株及其100微克/毫升耐利福平变异株对小鼠的毒力进行比较，结果显示，通过腹腔注射攻击，其中2株耐药变异株的毒力低于敏感菌株，而通过静脉注射攻击，3株耐药变异株的毒力较低（P<0.05）。
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