Ongini E, Parravicini L, Bamonte F
Arch Int Pharmacodyn Ther. 1981 Sep;253(1):164-76.
The interactions between physostigmine and chlordiazepoxide, diazepam, flurazepam were experimentally evaluated in rats and mice by the following test: loss of righting reflex (LRR), acute toxicity, cardiovascular toxicity and EEG pattern. Physostigmine did not modify the duration of LRR produced by chlordiazepoxide. Conversely, the recovery after diazepam was significantly longer. The LD50 of diazepam and chlordiazepoxide were not modified by physostigmine administration, but that of flurazepam was significantly decreased. Heart rate and blood pressure did not change significantly with physostigmine pre-treatment. However, the total lethal dose was lowered for chlordiazepoxide and flurazepam. Only the reversal by physostigmine of the EEG pattern due to benzodiazepines, offers experimental support to the claimed usefulness of physostigmine in benzodiazepine intoxication in humans. Furthermore, the potentiation of flurazepam toxicity must be taken into account in the debate concerning the clinical advantages of physostigmine.
通过以下试验在大鼠和小鼠中对毒扁豆碱与氯氮卓、地西泮、氟西泮之间的相互作用进行了实验评估：翻正反射消失（LRR）、急性毒性、心血管毒性和脑电图模式。毒扁豆碱未改变氯氮卓引起的翻正反射消失持续时间。相反，地西泮后的恢复时间显著延长。给予毒扁豆碱后，地西泮和氯氮卓的半数致死量（LD50）未改变，但氟西泮的LD50显著降低。毒扁豆碱预处理后心率和血压无显著变化。然而，氯氮卓和氟西泮的总致死剂量降低。只有毒扁豆碱对苯二氮卓类药物引起的脑电图模式的逆转，为毒扁豆碱在人类苯二氮卓类药物中毒中声称的有效性提供了实验支持。此外，在关于毒扁豆碱临床优势的辩论中，必须考虑氟西泮毒性的增强。
