Walz M A, Davis W M
Drug Chem Toxicol. 1979;2(3):257-67. doi: 10.3109/01480547908998247.
The ability of physostigmine and naloxone to reverse the loss of righting reflex (LRR) induced by diazepam was tested in mice and rats. Physostigmine was ineffective under our test conditions, but high doses of naloxone reduced the duration of LRR in both species. However, the LD50 of diazepam in mice was unaltered by 100 or 150 mg/kg of naloxone given 1 hr after LRR to model an antidotal situation. Use of a longer duration narcotic antagonist, naltrexone (172 mg/kg), in the same design likewise failed to elevate the LD50 for diazepam. These data give limited support to prior suggestions for clinical usefulness of naloxone, although not for physostigmine, in the management of intoxication caused by diazepam.
在小鼠和大鼠中测试了毒扁豆碱和纳洛酮逆转地西泮诱导的翻正反射丧失（LRR）的能力。在我们的测试条件下毒扁豆碱无效，但高剂量的纳洛酮缩短了两种动物的LRR持续时间。然而，在LRR后1小时给予100或150mg/kg纳洛酮以模拟解毒情况，小鼠地西泮的半数致死量（LD50）未改变。在相同设计中使用作用时间更长的麻醉拮抗剂纳曲酮（172mg/kg）同样未能提高地西泮的LD50。这些数据为先前关于纳洛酮（而非毒扁豆碱）在处理地西泮中毒方面临床实用性的建议提供了有限支持。
