Spina-França A, Nóbrega J P
Arq Neuropsiquiatr. 1981 Sep;39(3):279-85. doi: 10.1590/s0004-282x1981000300002.
The effectiveness of praziquantel on the infestation of the central nervous system by Cysticercus cellulosae is evaluated considering observations of 20 patients followed from July, 1979 and October, 1980. Two series of 6 day oral administration of the drug were scheduled for each patient: 20 mg/kg/day were given to the first 10 patients in the two series and 30 mg/kg/day to the second 10 patients in the two series. Transient exhacerbation of the cerebrospinal fluid changes proper to neurocysticercosis coincidental the series of medication was the mainline to consider the results. Cytologic aspects of this response was previously reported, and the remarkable participation of eosinophil cells was pointed out. It occurred in 15 patients. Corticosteroids interfere both in the intensity and in the type of this response. Data support the action of praziquantel on cysticerci which parasites the central nervous system and suggest the use of larger doses of the drug and/or a larger period of administration to obtain more effective results.
通过对1979年7月至1980年10月期间随访的20例患者的观察，评估了吡喹酮对猪囊尾蚴侵犯中枢神经系统的疗效。为每位患者安排了两个为期6天的口服给药疗程：两个疗程中的前10名患者给予20mg/kg/天，后10名患者给予30mg/kg/天。在用药疗程中，神经囊尾蚴病特有的脑脊液变化出现短暂加重是评估结果时要考虑的主要方面。此前已报道了这种反应的细胞学特征，并指出嗜酸性粒细胞有显著参与。15例患者出现了这种情况。皮质类固醇会影响这种反应的强度和类型。数据支持吡喹酮对寄生在中枢神经系统的囊尾蚴的作用，并建议使用更大剂量的药物和/或更长的给药时间以获得更有效的结果。
