驻留小鼠腹腔巨噬细胞中磷脂酶C活性的鉴定与特性研究。吩噻嗪类对该酶的抑制作用。
Identification and characterization of a phospholipase C activity in resident mouse peritoneal macrophages. Inhibition of the enzyme by phenothiazines.
作者信息
Wightman P D, Dahlgren M E, Hall J C, Davies P, Bonney R J
出版信息
Biochem J. 1981 Aug 1;197(2):523-6. doi: 10.1042/bj1970523.
Abstract
Resident mouse peritoneal macrophages contain a phospholipase C of high activity that is specific for phosphatidylinositol. The activity has a neutral pH optimum, is Ca(2+)-dependent and has a maximum reaction velocity of 525nmol/h per mg of protein. Certain phenothiazines are potent inhibitors of this activity.
摘要
驻留小鼠腹膜巨噬细胞含有一种对磷脂酰肌醇具有高活性的磷脂酶C。该活性的最适pH为中性，依赖Ca(2+)，每毫克蛋白质的最大反应速度为525nmol/h。某些吩噻嗪类是这种活性的有效抑制剂。
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