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暴露于60赫兹电场的啮齿动物的生长与代谢

Growth and metabolism of rodents exposed to 60-Hz electric fields.

作者信息

Hilton D I, Phillips R D

出版信息

Bioelectromagnetics. 1981;2(4):381-90. doi: 10.1002/bem.2250020409.

DOI:10.1002/bem.2250020409
PMID:7326059
Abstract

There have been a number of reports in the literature concerning growth-related changes in various animal species exposed to high-strength electric fields. Many of the laboratories reporting such effects have not documented and controlled for the secondary factors that are associated with generating high-strength electric fields (ie, corona, ozone, harmonic distortion, cage vibration, spark discharge). We have designed an exposure system in which we eliminated or minimized these secondary factors, therefore enabling us to examine only the effects of electric fields per se. Sprague-Dawley rats and Swiss-Webster mice were exposed to 60-Hz electric fields at kV/m for up to four months. In 17 individual experiments, we found a greater number of experiments in which the exposed rats had lower body weights than controls. This trend was not evident in data obtained from 14 individual mouse experiments. In more exhaustive growth studies, we found no significant differences in body weights, organ weights, or O2 consumption between exposed and sham-exposed controls. Our failure to detect any major changes in growth was probably the result of eliminating or minimizing the secondary factors associated with electric field exposure.

摘要

文献中有许多关于暴露于高强度电场的各种动物物种生长相关变化的报告。许多报告此类效应的实验室并未记录和控制与产生高强度电场相关的次要因素(即电晕、臭氧、谐波失真、笼子振动、火花放电)。我们设计了一种暴露系统,在该系统中我们消除或最小化了这些次要因素,从而使我们能够仅研究电场本身的效应。将斯普拉格-道利大鼠和瑞士-韦伯斯特小鼠暴露于高达千伏/米的60赫兹电场中长达四个月。在17项独立实验中,我们发现与对照组相比,暴露大鼠体重较低的实验数量更多。在从14项独立小鼠实验获得的数据中,这种趋势并不明显。在更详尽的生长研究中,我们发现暴露组与假暴露对照组之间在体重、器官重量或氧气消耗方面没有显著差异。我们未能检测到生长方面的任何重大变化,可能是消除或最小化与电场暴露相关的次要因素的结果。

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