淀粉样蛋白在AKR衰老小鼠关节结构中的沉积。

Amyloid deposition in the articular structures of AKR senescent mice.

作者信息

Shimizu K, Kasai R, Yamamuro T, Hosokawa M, Takeshita S, Takeda T

出版信息

Arthritis Rheum. 1981 Dec;24(12):1540-3. doi: 10.1002/art.1780241213.

Abstract

Amyloid deposition in the articular structures occurred with high frequency in a strain of mice now being established as an animal model of senescence in this laboratory. The changes were most evident in the knee joint. Peripheral joints were always spared. The lesions appeared after 7 months of age, and the incidence reached 88% (7 of 8) in autopsied mice over 8 months of age. This is the first report of amyloid deposition in the joints of laboratory animals.

摘要

在本实验室目前正在建立的一种作为衰老动物模型的小鼠品系中，关节结构中的淀粉样蛋白沉积频繁发生。这些变化在膝关节最为明显。外周关节总是幸免。病变在7个月大时出现，在8个月以上尸检的小鼠中发病率达到88%（8只中的7只）。这是关于实验动物关节中淀粉样蛋白沉积的首次报告。