• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Studies of chromophores in model membranes by polarized light-absorption spectroscopy. The orientation and binding of tetracaine and procaine.通过偏振光吸收光谱法对模型膜中发色团的研究。丁卡因和普鲁卡因的取向与结合。
Biophys J. 1981 Dec;36(3):735-41. doi: 10.1016/S0006-3495(81)84762-5.
2
Determination of procaine and related local anesthetics. I. Partition chromatographic separation and assay of mixtures of procaine with tetracaine and with propoxycaine.
J Assoc Off Anal Chem. 1975 Jan;58(1):88-92.
3
Multiple binding sites for local anesthetics in membranes: characterization of the sites and their equilibria by deuterium NMR of specifically deuterated procaine and tetracaine.膜中局部麻醉药的多个结合位点：通过特异性氘代普鲁卡因和丁卡因的氘核磁共振对位点及其平衡进行表征
Can J Biochem. 1980 Oct;58(10):986-95. doi: 10.1139/o80-134.
4
Determination of procaine and related local anesthetics. II. Collaborative study.
J Assoc Off Anal Chem. 1975 Jan;58(1):93-4.
5
[Qualitative and quantitative determination of procaine-, lidocaine- and tetracaine hydrochloride in drugs by means of capillary isotachophoresis].
Arzneimittelforschung. 1982;32(8):795-8.
6
Interaction of local anesthetics with lipid bilayers investigated by ¹H MAS NMR spectroscopy.通过¹H MAS NMR光谱研究局部麻醉剂与脂质双层的相互作用。
Biochim Biophys Acta. 2012 Dec;1818(12):3010-8. doi: 10.1016/j.bbamem.2012.07.014. Epub 2012 Jul 25.
7
Rapid analysis of tetracaine for a tape stripping pharmacokinetic study using short-end capillary electrophoresis.
Biomed Chromatogr. 2009 May;23(5):488-91. doi: 10.1002/bmc.1142.
8
[Commonly used local anaesthetic-sensitive field effect transistor: its development and applications].
Yao Xue Xue Bao. 1988;23(9):688-92.
9
Determination of ester-type local anesthetic drugs (procaine, tetracaine, and T-caine) in human serum by wide-bore capillary gas chromatography with nitrogen-phosphorus detection.
J Anal Toxicol. 1996 Sep;20(5):318-22. doi: 10.1093/jat/20.5.318.
10
[Quantitative regeneration of organic bases precipitated under the form of tetraphenylboride].
J Pharm Belg. 1966 Jul-Aug;21(7):363-74.

本文引用的文献

1
Local anaesthetics. VI. Relation between blocking potency and penetration of a monomolecular layer of lipoids from nerves.局部麻醉药。VI. 神经脂质单分子层的阻滞效能与穿透之间的关系。
Acta Pharmacol Toxicol (Copenh). 1954;10(4):325-37. doi: 10.1111/j.1600-0773.1954.tb01349.x.
2
Orientation and mobility of molecules in membranes studied by polarized light spectroscopy.
Q Rev Biophys. 1980 Feb;13(1):63-118. doi: 10.1017/s0033583500000317.
3
Nuclear magnetic resonance spectroscopic studies of procaine hydrochloride and tetracaine hydrochloride at lipid-water interfaces.盐酸普鲁卡因和盐酸丁卡因在脂质-水界面的核磁共振光谱研究。
Biochim Biophys Acta. 1969;183(3):466-75. doi: 10.1016/0005-2736(69)90161-8.
4
The importance of the hydrophobic interactions of local anesthetics in the displacement of polyvalent cations from artificial lipid membranes.局部麻醉药在从人工脂质膜置换多价阳离子过程中疏水相互作用的重要性。
Biochim Biophys Acta. 1973 Feb 27;298(1):8-14. doi: 10.1016/0005-2736(73)90003-5.
5
The membrane actions of anesthetics and tranquilizers.麻醉剂和镇静剂的膜作用。
Pharmacol Rev. 1972 Dec;24(4):583-655.
6
Studies on the mechanism of action of local anesthetics with phospholipid model membranes.利用磷脂模型膜对局部麻醉药作用机制的研究。
Biochim Biophys Acta. 1972 Apr 18;265(2):169-86. doi: 10.1016/0304-4157(72)90001-9.
7
Deuterium magnetic resonance: theory and application to lipid membranes.氘磁共振：脂质膜的理论与应用
Q Rev Biophys. 1977 Aug;10(3):353-418. doi: 10.1017/s0033583500002948.

通过偏振光吸收光谱法对模型膜中发色团的研究。丁卡因和普鲁卡因的取向与结合。

Studies of chromophores in model membranes by polarized light-absorption spectroscopy. The orientation and binding of tetracaine and procaine.

作者信息

Johansson L B, Lindblom G

出版信息

Biophys J. 1981 Dec;36(3):735-41. doi: 10.1016/S0006-3495(81)84762-5.

DOI:10.1016/S0006-3495(81)84762-5
PMID:7326331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1327656/
Abstract

A method for studying the orientation and binding of chromophores in macroscopically aligned membranes by polarized light absorption spectroscopy is described. Here tetracaine and procaine solubilized in a lamellar phase of octanoyl-1-glyceride (monooctanoin) and water have been investigated. Tetracaine is found to be located in the lipid region with a preferential orientation of the molecular long axis parallel to the hydrocarbon chains. The orientation of procaine, mainly residing in the water region, is very small.

摘要

描述了一种通过偏振光吸收光谱研究发色团在宏观排列膜中的取向和结合的方法。本文研究了溶解在辛酰基-1-甘油（单辛精）和水的层状相中丁卡因和普鲁卡因。发现丁卡因位于脂质区域，分子长轴优先平行于烃链取向。主要存在于水区域的普鲁卡因的取向非常小。