Korotkov K O, Zhulin V V, Kruglikov R I
Biull Eksp Biol Med. 1981 Dec;92(12):695-6.
In-vitro experiments were made to compare specific binding of 3H-diazepam with synaptic membranes obtained from the large hemispheres of rats trained the defense conditioned reflex to that in rats exposed to non-combined stimuli (active control). Within the concentration range of 0.37 nM-30 nM, specific binding of 3H-diazepam with the synaptic membranes obtained from the brain of active control animals was considerably higher than that with the synaptic membranes obtained from the trained animals brain.
进行了体外实验,以比较3H-地西泮与从接受防御性条件反射训练的大鼠大脑半球获得的突触膜的特异性结合,以及与暴露于非联合刺激的大鼠(活性对照)的突触膜的特异性结合。在0.37 nM-30 nM的浓度范围内,3H-地西泮与活性对照动物大脑获得的突触膜的特异性结合显著高于与训练动物大脑获得的突触膜的特异性结合。