Aalkjaer C, Mulvany M J
Blood Vessels. 1981;18(6):233-44. doi: 10.1159/000158357.
We have examined the functional and morphological properties of arterial resistance vessels with lumen diameters about 200 micrometer from the human omentum. The vascular smooth muscle cells were circumferentially oriented and arranged in about 3 layers within the media. The cells, when held at a length where their contractile response was maximal, were 97 micrometer long and had a mean diameter of 3.9 micrometer. In response to maximum potassium stimulation the force developed per cell was 2.4 micro N. The maximum response to norepinephrine (NE) was about 90% of the response to potassium, while the sensitivity to NE (NE-ED 50 = 0.4 micro M) was about the same as the NE sensitivity reported for larger human vessels. The sensitivity to NE was unaffected by cocaine, while the response to potassium was unaffected by phentolamine. Fluorescence microscopy indicated that the vessels contained few adrenergic nerve terminals. These findings suggest that although the vessels are well supplied with alpha-receptor, the vessels are only of minor importance for sympathetic blood pressure control.
我们已经研究了来自人网膜的管腔直径约200微米的动脉阻力血管的功能和形态学特性。血管平滑肌细胞呈周向排列，在中膜内约排列成3层。当细胞处于其收缩反应最大的长度时，细胞长97微米，平均直径为3.9微米。对最大钾刺激的反应中，每个细胞产生的力为2.4微牛。对去甲肾上腺素（NE）的最大反应约为对钾反应的90%，而对NE的敏感性（NE-ED 50 = 0.4微摩）与报道的较大人类血管对NE的敏感性大致相同。对NE的敏感性不受可卡因影响，而对钾的反应不受酚妥拉明影响。荧光显微镜检查表明，这些血管含有很少的肾上腺素能神经末梢。这些发现表明，尽管这些血管有丰富的α受体，但它们对交感神经血压控制的重要性较小。
