Gotoh S
Clin Ther. 1981;4 Suppl A:8-17.
Cefazolin and gentamicin were administered to mice with polymicrobial infection by Escherichia coli and Pseudomonas aeruginosa. Changes in the quantities of these bacteria in blood were investigated. Bacterial replacement was evident. Cefazolin was administered to mice with polymicrobial infection by E. coli and Bacteroides fragilis. Cefazolin was inactivated by B. fragilis-produced beta-lactamases. It was confirmed that the quantities of both B. fragilis and E. coli in blood increased. Even broad-spectrum antibiotics have different antibacterial activity against various bacteria. The present study suggested that an appropriate administration schedule should be determined to first inhibit the growth of a highly resistant bacterium in polymicrobial infection. It was also suggested that an antibiotic that can inhibit the growth of a more resistant bacterium should first be administered in polymicrobial infection. In vivo antibacterial activity of broad-spectrum antibiotics should be separately evaluated in mono-microbial infection and polymicrobial infection.
将头孢唑林和庆大霉素给予由大肠杆菌和铜绿假单胞菌引起的多微生物感染的小鼠。研究了这些细菌在血液中的数量变化。细菌替代现象明显。将头孢唑林给予由大肠杆菌和脆弱拟杆菌引起的多微生物感染的小鼠。头孢唑林被脆弱拟杆菌产生的β-内酰胺酶灭活。已证实血液中脆弱拟杆菌和大肠杆菌的数量均增加。即使是广谱抗生素对不同细菌也有不同的抗菌活性。本研究表明，应确定适当的给药方案，首先抑制多微生物感染中高度耐药细菌的生长。还表明，在多微生物感染中应首先给予能抑制更耐药细菌生长的抗生素。广谱抗生素的体内抗菌活性应在单微生物感染和多微生物感染中分别进行评估。
