文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Woods R L, Johnston C I

Clin Exp Pharmacol Physiol. 1981 Sep-Oct;8(5):519-23. doi: 10.1111/j.1440-1681.1981.tb00760.x.

Homozygous Brattleboro rats with hereditary hypothalamic diabetes insipidus (DI) developed one-kidney, one-clip (1K-1C) and two-kidney, one-clip (2K-1C) Goldblatt renal hypertension. 2. However, the systolic blood pressure (SBP) in 1K-1C Brattleboro rats was significantly lower than in non-DI hypertensive 1K-1C Long-Evans (LE) rats. 3. Treatment with the synthetic antidiuretic analogue of vasopressin, DDAVP (1-desamino-8-D-arginine vasopressin), increased the SBP in the DI rats to the same level as in 1K-1C Long-Evans. This elevation of SBP was associated with increased extracellular fluid volume in the DI rats after DDAVP. 4. The results suggest that vasopressin is not essential for the development of renal hypertension but the absolute levels of blood pressure achieved in 1K-1C hypertension are volume-dependent and thus influenced by the water-retaining properties of vasopressin.

患有遗传性下丘脑性尿崩症（DI）的纯合布拉特洛伯大鼠发生了单肾单夹（1K-1C）和双肾单夹（2K-1C）戈德布拉特肾性高血压。2. 然而，1K-1C布拉特洛伯大鼠的收缩压（SBP）显著低于非DI高血压1K-1C长 Evans（LE）大鼠。3. 用加压素的合成抗利尿类似物去氨加压素（1-去氨基-8-D-精氨酸加压素，DDAVP）治疗后，DI大鼠的SBP升高至与1K-1C长Evans大鼠相同的水平。DDAVP治疗后，DI大鼠的SBP升高与细胞外液量增加有关。4. 结果表明，加压素对于肾性高血压的发生并非必不可少，但1K-1C高血压所达到的绝对血压水平依赖于血容量，因此受加压素保水特性的影响。

Woods R L, Johnston C I

Clin Exp Pharmacol Physiol. 1981 Sep-Oct;8(5):519-23. doi: 10.1111/j.1440-1681.1981.tb00760.x.

Homozygous Brattleboro rats with hereditary hypothalamic diabetes insipidus (DI) developed one-kidney, one-clip (1K-1C) and two-kidney, one-clip (2K-1C) Goldblatt renal hypertension. 2. However, the systolic blood pressure (SBP) in 1K-1C Brattleboro rats was significantly lower than in non-DI hypertensive 1K-1C Long-Evans (LE) rats. 3. Treatment with the synthetic antidiuretic analogue of vasopressin, DDAVP (1-desamino-8-D-arginine vasopressin), increased the SBP in the DI rats to the same level as in 1K-1C Long-Evans. This elevation of SBP was associated with increased extracellular fluid volume in the DI rats after DDAVP. 4. The results suggest that vasopressin is not essential for the development of renal hypertension but the absolute levels of blood pressure achieved in 1K-1C hypertension are volume-dependent and thus influenced by the water-retaining properties of vasopressin.

患有遗传性下丘脑性尿崩症（DI）的纯合布拉特洛伯大鼠发生了单肾单夹（1K-1C）和双肾单夹（2K-1C）戈德布拉特肾性高血压。2. 然而，1K-1C布拉特洛伯大鼠的收缩压（SBP）显著低于非DI高血压1K-1C长 Evans（LE）大鼠。3. 用加压素的合成抗利尿类似物去氨加压素（1-去氨基-8-D-精氨酸加压素，DDAVP）治疗后，DI大鼠的SBP升高至与1K-1C长Evans大鼠相同的水平。DDAVP治疗后，DI大鼠的SBP升高与细胞外液量增加有关。4. 结果表明，加压素对于肾性高血压的发生并非必不可少，但1K-1C高血压所达到的绝对血压水平依赖于血容量，因此受加压素保水特性的影响。