Thaler L M, Brandes J M, Sideman S
Int J Artif Organs. 1981 Jul;4(4):192-8.
Removal of bilirubin by hemoperfusion (HP) on a macroreticular ion-exchange resin is suggested as a novel clinical procedure for the treatment of jaundiced newborn babies. The efficiency and biocompatibility of the proposed macroreticular (MR) ion exchange column was tested in vivo with jaundiced dogs. An animal model with a choledocho-suprarenal vein shunting allowed to test the column capacity for the adsorption of conjugated and unconjugated bilirubin. A second animal model, based on infusing unconjugated bilirubin directly into the blood stream, enabled to test the column operation at desired unconjugated bilirubin concentrations. The results of the in vivo hemoperfusion tests are very encouraging and compare favorably with bilirubin removal from babies by exchange transfusion (ET). Operating a column containing 10 ml resin per kg body weight for 3 hours removed over 1.7 times the initial unconjugated bilirubin content. Furthermore, the animals seemed to be unaffected by the HP procedure; the changes due to hemoperfusion on blood chemistry, hematology and some hormone levels were practically insignificant.
有人提出，采用大孔网状离子交换树脂进行血液灌流（HP）以清除胆红素，作为治疗新生儿黄疸的一种新的临床方法。在黄疸犬体内对所提出的大孔网状（MR）离子交换柱的效率和生物相容性进行了测试。一种胆总管-肾上腺静脉分流的动物模型用于测试该柱对结合胆红素和未结合胆红素的吸附能力。另一种基于将未结合胆红素直接注入血流的动物模型，能够在所需的未结合胆红素浓度下测试该柱的运行情况。体内血液灌流试验的结果非常令人鼓舞，与通过换血疗法（ET）从婴儿体内清除胆红素的效果相比更具优势。以每千克体重10毫升树脂的柱运行3小时，可清除超过初始未结合胆红素含量1.7倍的胆红素。此外，动物似乎未受血液灌流程序的影响；血液灌流对血液化学、血液学和一些激素水平的影响实际上微不足道。
