Sideman S, Mor L, Brandes J M, Lupovitch S
J Biomed Mater Res. 1983 Jan;17(1):91-107. doi: 10.1002/jbm.820170109.
Removal of bilirubin by hemoperfusion with ion exchange resin particles is suggested to replace exchange transfusion of blood of jaundiced infants in some cases of unconjugated hyperbilirubinemia. The hemoperfusion system developed here consists of a packed bed of a macroreticular resin which is made biocompatible by a coating of a monomolecular layer of albumin. The choice of the appropriate ionic form of the resin and the proper albumin coating and crosslinking procedure assures a high bilirubin adsorption capacity and excellent blood compatibility of the resin. The albumin coated resin removes in vitro 80-90% of the bilirubin initially present in the plasma. The results encourage in vivo clinical studies.
在某些非结合性高胆红素血症病例中，建议采用离子交换树脂颗粒血液灌流去除胆红素，以替代黄疸婴儿的换血疗法。此处研发的血液灌流系统由大孔网状树脂填充床组成，该树脂通过单分子层白蛋白涂层实现生物相容性。选择树脂的适当离子形式以及合适的白蛋白涂层和交联程序，可确保树脂具有高胆红素吸附能力和出色的血液相容性。白蛋白包被的树脂在体外可去除血浆中最初存在的80%-90%的胆红素。这些结果鼓励进行体内临床研究。
