Hormonal regulation of chymotrypsin-like esteroproteases in the mouse submandibular gland.

The activities of chymotrypsin-like esteroproteases in the mouse submandibular gland were additively induced by 5 alpha-dihydrotestosterone (DHT) and triiodothyronine (T3). Zymograms showed that there are many isozymes whose activities are regulated by DHT and/or T3. Some isozymes seemed to be hormone-independent. Histochemical studies revealed that all these isozymes are localized in the granular convoluted tubules.