Brady K D, Majumdar S K
J Hered. 1981 Sep-Oct;72(5):347-50. doi: 10.1093/oxfordjournals.jhered.a109520.
5-thio-D-glucose at 40 mg/kg body weight was administered daily by intraperitoneal injections to male C3H mice. The animals were studied via direct counts of the spermatogenic cells in histologic sections of the testes. These revealed the selective loss or injury of early spermatids followed later in treatment by significantly diminished spermatocyte number. Spermatogonia and Sertoli cells were not significantly affected by thiosugar. After 35 daily doses, testicular and epithelium was noted. The results are indicative of an early drug action on spermatids with later effects on spermatocytes. Recovery began within three weeks of drug withdrawal and was characterized by restoration of the severely disturbed architecture and with the progressive resumption of spermatogenesis. Epididymis sperm counts returned to 91 percent that of control animals; however, testis weights remained somewhat below normal.
将体重40毫克/千克的5-硫代-D-葡萄糖每日通过腹腔注射给予雄性C3H小鼠。通过对睾丸组织切片中的生精细胞进行直接计数来研究这些动物。这些结果显示早期精子细胞选择性丢失或受损，随后在治疗过程中精母细胞数量显著减少。精原细胞和支持细胞未受到硫糖的显著影响。在每日给药35次后，观察到睾丸和上皮组织的变化。结果表明该药物对精子细胞有早期作用，随后对精母细胞产生影响。停药三周内开始恢复，其特征是严重紊乱的结构得以恢复，生精过程逐渐恢复。附睾精子计数恢复到对照动物的91%；然而，睾丸重量仍略低于正常水平。
