Majumdar S K, Brady K D, Ringer L D, Natoli J, Killian C M, Portnoy J A, Koury P
J Hered. 1979 Mar-Apr;70(2):142-5. doi: 10.1093/oxfordjournals.jhered.a109212.
Under the conditions of the present study, 5-thio-D-glucose was found to be an effective and useful reversible male contraceptive. Treatment of male mice with 5-thio, administered intraperitoneally or orally at 40 or 60 mg/kg for 28 to 35 days produced germinal cell degeneration and complete inhibition of spermatogenesis in the seminiferous tubules. These treatment regimens also resulted in complete sterility in males lasting for several weeks. Resumption of sperm development and fertility occurred with 5 to 6 weeks after treatment was discontinued. The Leydig cell population, Sertoli cells, and spermatogonia apparently were not affected and male libido was not impaired. There was no evidence of embryotoxic or teratogenic effect in litters of pregnant females treated orally with 5-thio on days 6--12 of gestation.
在本研究条件下，发现5-硫代-D-葡萄糖是一种有效且有用的可逆性男性避孕药。以40或60mg/kg的剂量腹腔内或口服给予雄性小鼠5-硫代物，持续28至35天，可导致生精细胞变性并完全抑制生精小管中的精子发生。这些治疗方案还导致雄性小鼠完全不育，持续数周。在停药后5至6周，精子发育和生育能力恢复。睾丸间质细胞、支持细胞和精原细胞显然未受影响，雄性性欲也未受损。在妊娠第6至12天口服5-硫代物治疗的怀孕雌性小鼠所产仔鼠中，没有胚胎毒性或致畸作用的证据。
