Kraus J F, Mull R, Kurtz P, Winterlin W, Franti C E, Borhani N, Kilgore W
J Toxicol Environ Health. 1981 Jul-Aug;8(1-2):169-84. doi: 10.1080/15287398109530061.
Biological parameters associated with organophosphate (OP) pesticide exposure were evaluated in a study of citrus harvesters. Changes in these parameters related to environmental residues of cholinesterase (ChE) inhibiting pesticides were studied. Further, it was determined whether usual and volunteer workers differed in their biochemical parameters after exposure to pesticide residues during field operations. Urine metabolite findings for usual farm workers showed that some exposure to OP pesticides had occurred. Too few workers were available during the reentry stage of the field study to evaluate the effect of this exposure on blood ChE. Baseline (nonexposure) acetylcholinesterase (AChE) and plasma cholinesterase (PChE) activities were significantly higher in usual (Mexican American) workers than in volunteer workers (student volunteers). Student volunteers in the test citrus grove showed statistically significant declines in PChE during the exposure period, yet changes in AChE activity, urine metabolites, and residue levels were very small. The implications of these findings are discussed in light of current reentry standards as well as future epidemiologic studies on reentry research.
在一项针对柑橘采摘工人的研究中，对与有机磷（OP）农药接触相关的生物学参数进行了评估。研究了这些参数与抑制胆碱酯酶（ChE）的农药环境残留量之间的关系。此外，还确定了长期工人和志愿工人在田间作业接触农药残留后，其生化参数是否存在差异。长期农场工人的尿液代谢物检测结果表明，他们曾接触过OP农药。在田间研究的重新进入阶段，可用的工人数量太少，无法评估这种接触对血液ChE的影响。长期（墨西哥裔美国人）工人的基线（未接触）乙酰胆碱酯酶（AChE）和血浆胆碱酯酶（PChE）活性显著高于志愿工人（学生志愿者）。在试验柑橘园中，学生志愿者在接触期间PChE出现了具有统计学意义的下降，但AChE活性、尿液代谢物和残留水平的变化非常小。结合当前的重新进入标准以及未来关于重新进入研究的流行病学研究，对这些发现的意义进行了讨论。
