Gillissen G
Methods Find Exp Clin Pharmacol. 1981 Sep-Oct;3(5):297-302.
Experiments were performed investigating the actual role of Omnadin by itself or together with the bactericidal antibiotic Penicillin in therapy of infections. Mice were infected with a Staph. aureus strain exhibiting a very high resistance to penicillin. It could be shown that Omnadin, even when given alone and as single dose, improves bacterial defence. Together with penicillin, it increases the antibiotic effect considerably. Also in these experiments, Omnadin was given only once. Furthermore, it was examined whether this effect may be due to a stimulation of the immune system. The experiments showed that Omnadin enhances antibody production as demonstrated by the increased number of antibody forming cells. This effect concerns IgM- as well as IgG- antibodies. The observation that not only the IgM- but also the IgG- antibodies are increased early after immunization and application of Omnadin suggests also a possible acceleration of the switch from IgM- to IgG- production. In addition, a direct influence of Omnadin on different lymphocyte classes in vitro was assayed by evaluating the rate of transformation. It could be shown that T- and B-cells are activated. The therapeutic effect on Omnadin alone and particularly in combination with penicillin is therefore explained by its stimulating effect on the immune response.
进行了多项实验，以研究奥姆那丁单独使用或与杀菌抗生素青霉素联合使用在感染治疗中的实际作用。用对青霉素具有极高抗性的金黄色葡萄球菌菌株感染小鼠。结果表明，奥姆那丁即使单独单次给药，也能改善细菌防御能力。与青霉素联合使用时，它能显著增强抗生素效果。在这些实验中，奥姆那丁也仅给药一次。此外，还研究了这种效果是否可能归因于对免疫系统的刺激。实验表明，奥姆那丁可增强抗体产生，这可通过抗体形成细胞数量的增加得以证明。这种效果涉及IgM抗体和IgG抗体。不仅IgM抗体，而且IgG抗体在免疫和应用奥姆那丁后早期均增加，这一观察结果也表明可能加速了从IgM产生向IgG产生的转换。此外，通过评估转化速率来测定奥姆那丁在体外对不同淋巴细胞类别的直接影响。结果表明，T细胞和B细胞均被激活。因此，奥姆那丁单独使用，特别是与青霉素联合使用时的治疗效果，可通过其对免疫反应的刺激作用来解释。
