Gillissen G, Breuer-Werle M
Pathol Biol (Paris). 1983 Jun;31(6):548-50.
The effect of an immunomodulator, the Immunoferon (IF), on the course of experimental infections with Staphylococcus aureus and on cellular immune reactions (foot pad swelling test) was examined. The substance is a glycophosphopeptide adsorbed on sulfurized calcium phosphate. The IF improves clearly the therapeutic effect of penicillin, but has no significant effect when given alone. The substance neutralizes the negative effect of hydrocortisone on the therapeutic effectivity of penicillin. The cellular immune reaction is reduced by very small doses of IF, but is enhanced progressively by higher doses. The effect of hydrocortisone is abolished in this respect.
研究了一种免疫调节剂免疫干扰素（IF）对金黄色葡萄球菌实验性感染病程以及细胞免疫反应（足垫肿胀试验）的影响。该物质是一种吸附在硫化磷酸钙上的糖磷肽。IF能显著提高青霉素的治疗效果，但单独使用时无显著效果。该物质可中和氢化可的松对青霉素治疗效果的负面影响。极少量的IF会降低细胞免疫反应，但较高剂量会使其逐渐增强。在这方面，氢化可的松的作用被消除。
