Shah P M
Methods Find Exp Clin Pharmacol. 1981 Nov-Dec;3(6):387-90.
The in vitro activity of thienamycin was determined simultaneously in Müller-Hinton broth and peptone broth. Minimum inhibitory and bactericidal concentrations were compared to those of 4 aminoglycosides and 3 cefalosporins. The activity of thienamycin against gram-negative aerobic bacterial was influenced by the media. Peptone broth gave the lowest MICs and MBCs. Concentrations less than or equal to 8 mcg thienamycin/ml peptone broth inhibited 354 out of 382 strains tested.
在Müller-Hinton肉汤和蛋白胨肉汤中同时测定了硫霉素的体外活性。将最低抑菌浓度和杀菌浓度与4种氨基糖苷类药物和3种头孢菌素的浓度进行了比较。硫霉素对革兰氏阴性需氧菌的活性受培养基的影响。蛋白胨肉汤中的最低抑菌浓度和最低杀菌浓度最低。在蛋白胨肉汤中，硫霉素浓度小于或等于8微克/毫升时，可抑制382株受试菌株中的354株。
